Visual communication design is the process of transferring information to consumers through visual symbols. The goal is to make the message clearer and intuitive to the audience, helping them to understand the message more quickly and visually. In the process of information transmission, the audience will have psychological communication through these visual symbols and their psychology will be affected, so that they can finally understand the information. Through comparative analysis, empirical analysis and other methods, the psychological impact that design may have on the audience in the process of epidemic information transmission is analyzed from the perspective of color design, illustration image design, inforgraphic design and material design in the visual communication theory. The designer hopes that the method of visual communication design will positively affect the audience's psychology and form positive information guidance during the transmission of epidemic information, thus enhancing the audience’s awareness of prevention, reducing anxiety and giving warmth to the people after the disaster.