The people-centered nature of art in Xi Jinping's cultural thoughts serves as the soul of literary and artistic endeavors in the new era. The work aims to explore the profound logic and multidimensional origins of its formation from a theoretical perspective. Firstly, in terms of the "soul-vein", it "returns to the roots to innovate", transforming the Marxist materialist conception of history into the logical starting point of the aesthetic realm, thereby clarifying the fundamental value orientation of literature and art. Secondly, in terms of the "culture-vein", it transforms and elevates the people-centered essence of fine traditional Chinese culture into a contemporary discourse of "putting the people first", achieving a historical leap in aesthetic paradigms. Thirdly, in terms of the "blood-vein", it carries forward the "red gene" of the Communist Party of China's literary and artistic line, completing a mission upgrade from satisfying basic cultural needs to strengthening the people's spiritual power. Through the organic integration of these multiple threads, Xi Jinping's cultural thoughts successfully achieve a Sinicized leap in Marxist literary and artistic theory, providing a fundamental framework for constructing an independent Chinese knowledge system for literature and art.